Host-pathogen coevolution increases genetic variation in susceptibility to infection

Duxbury, Elizabeth Ml, Day, Jonathan P, Maria Vespasiani, Davide, Thüringer, Yannik, Tolosana, Ignacio, Smith, Sophia Cl, Tagliaferri, Lucia, Kamacioglu, Altug, Lindsley, Imogen, Love, Luca, Unckless, Robert L, Jiggins, Francis M and Longdon, Ben (2019) Host-pathogen coevolution increases genetic variation in susceptibility to infection. eLife, 8. ISSN 2050-084X

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Abstract

It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show more genetic variation in susceptibility to pathogens that they naturally encounter than novel pathogens. In a large cross-infection experiment involving four species of Drosophila and four host-specific viruses, we always found greater genetic variation in susceptibility to viruses that had coevolved with their host. We went on to examine the genetic architecture of resistance in one host species, finding that there are more major-effect genetic variants in coevolved host-pathogen interactions. We conclude that selection by pathogens has increased genetic variation in host susceptibility, and much of this effect is caused by the occurrence of major-effect resistance polymorphisms within populations.

Item Type: Article
Additional Information: © 2019, Duxbury et al.
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: LivePure Connector
Date Deposited: 01 May 2019 11:30
Last Modified: 18 May 2020 00:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/70768
DOI: 10.7554/eLife.46440

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