Factors determining human-to-human transmissibility of zoonotic pathogens via contact

Richard, Mathilde, Knauf, Sascha, Lawrence, Philip, Mather, Alison E, Munster, Vincent J, Müller, Marcel A, Smith, Derek and Kuiken, Thijs (2017) Factors determining human-to-human transmissibility of zoonotic pathogens via contact. Current Opinion in Virology, 22. pp. 7-12. ISSN 1879-6257

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Abstract

The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their human-to-human transmissibility via the following modes of contact transmission: skin contact, sexual contact, respiratory contact and multiple route contact. Factors common to several modes of transmission were immune evasion, high viral load, low infectious dose, crowding, promiscuity, and co-infections; other factors were specific for a pathogen or mode of contact transmission. The identification of such factors will lead to a better understanding of the requirements for human-to-human spread of pathogens, as well as improving risk assessment of newly emerging pathogens.

Item Type: Article
Faculty \ School:
Depositing User: LivePure Connector
Date Deposited: 24 Apr 2019 10:30
Last Modified: 26 Aug 2020 23:54
URI: https://ueaeprints.uea.ac.uk/id/eprint/70655
DOI: 10.1016/j.coviro.2016.11.004

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