ILC3 function as a double-edged sword in inflammatory bowel diseases

Zeng, Boning, Shi, Shengnan, Ashworth, Gareth, Dong, Changjiang, Liu, Jing and Xing, Feiyue (2019) ILC3 function as a double-edged sword in inflammatory bowel diseases. Cell Death & Disease, 10 (4). ISSN 2041-4889

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Abstract

Inflammatory bowel diseases (IBD), composed mainly of Crohn’s disease (CD) and ulcerative colitis (UC), are strongly implicated in the development of intestinal inflammation lesions. Its exact etiology and pathogenesis are still undetermined. Recently accumulating evidence supports that group 3 innate lymphoid cells (ILC3) are responsible for gastrointestinal mucosal homeostasis through moderate generation of IL-22, IL-17, and GM-CSF in the physiological state. ILC3 contribute to the progression and aggravation of IBD while both IL-22 and IL-17, along with IFN-γ, are overexpressed by the dysregulation of NCR− ILC3 or NCR+ ILC3 function and the bias of NCR+ ILC3 towards ILC1 as well as regulatory ILC dysfunction in the pathological state. Herein, we feature the group 3 innate lymphoid cells’ development, biological function, maintenance of gut homeostasis, mediation of IBD occurrence, and potential application to IBD therapy.

Item Type: Article
Faculty \ School: Faculty of Science > School of Environmental Sciences
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Depositing User: LivePure Connector
Date Deposited: 12 Apr 2019 15:30
Last Modified: 13 May 2020 23:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/70557
DOI: 10.1038/s41419-019-1540-2

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