Molecular mechanisms of antibiotic resistance

Blair, Jessica M A, Webber, Mark A., Baylay, Alison J., Ogbolu, David O. and Piddock, Laura J V (2015) Molecular mechanisms of antibiotic resistance. Nature Reviews Microbiology, 13 (1). pp. 42-51. ISSN 1740-1526

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Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.

Item Type: Article
Uncontrolled Keywords: immunology and microbiology(all),medicine(all) ,/dk/atira/pure/subjectarea/asjc/2400
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Depositing User: LivePure Connector
Date Deposited: 22 Mar 2019 11:30
Last Modified: 21 Oct 2022 21:43
DOI: 10.1038/nrmicro3380

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