Antimicrobial peptide coatings for hydroxyapatite:Electrostatic and covalent attachment of antimicrobial peptides to surfaces

Townsend, Leigh, Williams, Richard L., Anuforom, Olachi, Berwick, Matthew R., Halstead, Fenella, Hughes, Erik, Stamboulis, Artemis, Oppenheim, Beryl, Gough, Julie, Grover, Liam, Scott, Robert A.H., Webber, Mark, Peacock, Anna F.A., Belli, Antonio, Logan, Ann and De Cogan, Felicity (2017) Antimicrobial peptide coatings for hydroxyapatite:Electrostatic and covalent attachment of antimicrobial peptides to surfaces. Journal of The Royal Society Interface, 14 (126). ISSN 1742-5689

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Abstract

The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel method of modifying the surface at the material-tissue interface with an antimicrobial peptide (AMP) coating to allowcell attachment while inhibiting bacterial colonization. The technology reported here is a dual AMP coating. The dual coating consists ofAMPs covalently bonded to the hydroxyapatite surface, followed by deposition of electrostatically bound AMPs. The dual approach gives an efficacious coating which is stable for over 12 months and can prevent colonization of the surface by both Gram-positive and Gram-negative bacteria.

Item Type: Article
Uncontrolled Keywords: antimicrobial,device-tissue interface,surface engineering,biotechnology,biophysics,bioengineering,biomaterials,biochemistry,biomedical engineering ,/dk/atira/pure/subjectarea/asjc/1300/1305
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Depositing User: LivePure Connector
Date Deposited: 22 Mar 2019 10:30
Last Modified: 31 Oct 2019 15:35
URI: https://ueaeprints.uea.ac.uk/id/eprint/70304
DOI: 10.1098/rsif.2016.0657

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