Fluoroquinolone resistance:Mechanisms, impact on bacteria, and role in evolutionary success

Redgrave, Liam S., Sutton, Sam B., Webber, Mark A. and Piddock, Laura J V (2014) Fluoroquinolone resistance:Mechanisms, impact on bacteria, and role in evolutionary success. Trends in Microbiology, 22 (8). pp. 438-445. ISSN 0966-842X

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Abstract

Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly used to treat a range of infections. Resistance to these agents is multifactorial and can be via one or a combination of target-site gene mutations, increased production of multidrug-resistance (MDR) efflux pumps, modifying enzymes, and/or target-protection proteins. Fluoroquinolone-resistant clinical isolates of bacteria have emerged readily and recent data have shown that resistance to this class of antibiotics can have diverse, species-dependent impacts on host-strain fitness. Here we outline the impacts of quinolone-resistance mutations in relation to the fitness and evolutionary success of mutant strains.

Item Type: Article
Uncontrolled Keywords: chromosome structure,fitness,infectious diseases,microbiology (medical),microbiology,virology,medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700/2725
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 22 Mar 2019 09:30
Last Modified: 22 Apr 2020 07:37
URI: https://ueaeprints.uea.ac.uk/id/eprint/70298
DOI: 10.1016/j.tim.2014.04.007

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