Effect of high-intensity interval training in adolescents with asthma: the eXercise for Asthma with Commando Joe’s® (X4ACJ) trial

Winn, Charles O. N., Mackintosh, Kelly A., Eddolls, William T.B., Stratton, Gareth, Wilson, Andrew, McNarry, Melitta and Davies, Gwyneth (2019) Effect of high-intensity interval training in adolescents with asthma: the eXercise for Asthma with Commando Joe’s® (X4ACJ) trial. Journal of Sport and Health Science. ISSN 2213-2961

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Abstract

Background: Higher cardiorespiratory fitness is associated with reduced asthma severity and increased quality of life in those with asthma. Therefore, the purpose of this study was to evaluate the feasibility and effectiveness of a 6-month high-intensity interval training (HIIT) intervention in adolescents with and without asthma. Methods: A total of 616 adolescents (334 boys; 13.0±1.1 years; 1.57±0.10m; 52.6±12.9kg), including 155 with asthma (78 boys), were recruited as part of a randomised control trial from 5 schools (4 control, 1 intervention). The 221 intervention participants (116 boys; 47 asthma) completed 6-months school-based HIIT (3x30min, 10-30s bouts at >90% age-predicted maximum heart rate with equal rest). At baseline, mid-intervention, post-intervention and 3-months follow-up, measurements of 20-metre shuttle run, body mass index (BMI), lung function, Pediatric Quality of Life Inventory, Paediatric Asthma Quality of Life Questionnaire and Asthma Control Questionnaire were collected. Additionally, 69 adolescents (36 asthma; 21 boys) also completed an incremental ramp test. For analysis, each group’s data (intervention and control) was divided into those with and without asthma. Results: Participants with asthma did not differ from their peers in any parameter of aerobic fitness, at any time-point, but were characterised by a higher BMI. The intervention was associated with a significant improvement in maximal aerobic fitness but no change in sub-maximal parameters of aerobic fitness, lung function or quality of life, irrespective of asthma status. Those in the intervention group maintained their BMI, whereas BMI significantly increased in the control group throughout the 6-month period. Conclusions: HIIT represents an effective tool to improve aerobic fitness and maintain BMI in adolescents, irrespective of asthma status. HIIT was feasible and well-tolerated in those with asthma, who evidenced a similar aerobic fitness to their healthy peers and responded equally to a HIIT programme.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 12 Mar 2019 09:30
Last Modified: 11 Jun 2020 01:03
URI: https://ueaeprints.uea.ac.uk/id/eprint/70195
DOI: 10.1016/j.jshs.2019.05.009

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