Regional dynamics of the resting brain in amyotrophic lateral sclerosis using fALFF and ReHo analyses

Bueno, Ana, Pinaya, Walter Hugo Lopez, Rebello, Keila, Cruz de Souza, Leonardo, Hornberger, Michael and Sato, João Ricardo (2019) Regional dynamics of the resting brain in amyotrophic lateral sclerosis using fALFF and ReHo analyses. Brain Connectivity, 9 (4). ISSN 2158-0022

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Abstract

Resting state functional magnetic resonance imaging (rs-fMRI) has been playing an important role in the study of amyotrophic lateral sclerosis (ALS). Although functional connectivity is widely studied, the patterns of spontaneous neural activity of the resting brain are important mechanisms that have been used recently to study a variety of conditions but remain less explored in ALS. Here we have used fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) to study the regional dynamics of the resting brain of non-demented ALS patients compared with healthy controls. As expected, we found the sensorimotor network (SMN) with changes in fALFF and ReHo but also found the default mode (DMN), frontoparietal (FPN), salience (SN) networks altered and the cerebellum, although no structural changes between ALS patients and controls were reported in the regions with fALFF and ReHo changes. We show an altered pattern in the spontaneous low frequency oscillations that is not confined to the motor areas and reveal a more widespread involvement of non-motor regions, including those responsible for cognition.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 07 Mar 2019 15:30
Last Modified: 29 Jun 2020 23:56
URI: https://ueaeprints.uea.ac.uk/id/eprint/70181
DOI: 10.1089/brain.2019.0663

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