Tec family kinases in inflammation and disease

Horwood, Nicole J ORCID: https://orcid.org/0000-0002-6344-1677, Urbaniak, Ania M and Danks, Lynett (2012) Tec family kinases in inflammation and disease. Molecular Immunology, 31 (2). pp. 87-103. ISSN 0161-5890

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Abstract

Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell development and recent evidence showing that blocking Btk signaling is effective in ameliorating lymphoma progression and experimental arthritis. This review will examine the role of TFK in myeloid cell function and the potential of targeting these kinases as a therapeutic intervention in autoimmune disorders such as rheumatoid arthritis.

Item Type:	Article
Uncontrolled Keywords:	animals,drug therapy,drug therapy,therapeutic use,humans,metabolism,mice,cytology,antagonists & inhibitors
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	LivePure Connector
Date Deposited:	06 Mar 2019 12:30
Last Modified:	22 Oct 2022 04:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/70163
DOI:	10.3109/08830185.2012.670334

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