Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases

Ersek, Adel, Karadimitris, Anastasios and Horwood, Nicole J (2012) Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases. Frontiers in Endocrinology, 3. pp. 1-7. ISSN 1664-2392

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Abstract

Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher's disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as well as the potential therapeutic uses of already approved drugs that limit GSL production in bone loss disorders such as multiple myeloma and periodontal disease.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 06 Mar 2019 11:30
Last Modified: 18 Mar 2020 02:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/70148
DOI: 10.3389/fendo.2012.00106

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