%PDF-1.4
%
346 0 obj
<>>>
endobj
343 0 obj
<>stream
doi:bmjopen-2018-023765
application/pdf
2019-02-15T07:40:21Z
2019-03-01T05:59:43-08:00
2019-03-01T05:59:43-08:00
Adobe InDesign CS6 (Windows)
uuid:8ede9716-1dd2-11b2-0a00-5c00b8afa9ff
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
xmp.id:3D8106F0F430E91196A8D3AD1D3843A1
proof:pdf
xmp.iid:3C8106F0F430E91196A8D3AD1D3843A1
xmp.did:12BEE6AC550DE8118634A2E26D244B8E
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
default
converted
from application/x-indesign to application/pdf
Adobe InDesign CS6 (Windows)
/
2019-02-15T07:40:22Z
a13b929e-d720-4d95-b3d2-4ff391546002
Adobe PDF Library 10.0.1
False
endstream
endobj
347 0 obj
<>
endobj
248 0 obj
<>
endobj
340 0 obj
<>
endobj
341 0 obj
<>
endobj
342 0 obj
<>
endobj
73 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
80 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
91 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
96 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
101 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
200 0 obj
<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>>
endobj
201 0 obj
[202 0 R 203 0 R 204 0 R 205 0 R 206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 462 0 R]
endobj
459 0 obj
<>stream
H̗[sFuw854}%Jg&g<[F4"xȇi b
JA!JpwO2(QWI)^YzHaVz##iQp/,$pE0JZm:O-l^%.Z%>(Mе<@aZ 5@ƚ`P)`CT/D
JN>7)(2e(J-#"h:_rQ8'Cvܠk3MM 3FˎM]Vfv@BF:ROMGW-Ne ߶'ҐTLbҪsGLmeNSd=)@sR*3ɳ鬉EU {\:%ƺk_\\|JBCum0ОWU;IS|!! ǕI.3(w]ݶ'a8}] n.
H%S"SX¿;b;.t<2,&w
#m]Nx;O$[&)
OQC)7(w<}q\y{4_ix點Zvέ`^&c:|`[xD>?x%c^X'p!RmJpb86x}s,uaK=OügqG."YMQ1l?M3WdvLiRqd
]_qB)zཨ=FF:[x2sf,_"0x87}bT#M337Ⱥ^Fռ^Tayp^,wo8e>\
~$ SeS5$Ká?aQ͌)n\aao!B1ΊNǫsP}{&`}dp
kmʤ:Ts:_ֶȣrR{yw2pfu?ֳ=J$P;ڴٛ?BC0c7%qC"6D4L0x_E~>qIsprBq_!gB}5ٰIՀˇqe뉓4=AcMKڏDsڳ1lf&p%*w6Ғ7[
U66ܭ'EP %LqQW䣥Bj M\ԖAl%Q0`26p>P`SH塩Pv+l g&5`>M?FB$qlD?E/9y쎵(َ\WnjR1\H她6XoQw߹2M~
$r5I'6t>z.<s*>p8{ j{a=sC>oQYXQ"U 0<\$d]Ds^%Ye"(˗+:X݈(*{^Uy'2SWeI0C
=aj|1m9G XvLȵ.
c~U揋.p[>3=A"K`S` 3
endstream
endobj
236 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>/Subtype/Form>>stream
H\_K0笠)47Yt
d0"U+$H $=9'Qx^5re/y4c1}H46[X4ޡfLI7w@[Y;.¿a7)cˋI`qW)r~aw,a$ԚňBDWz7$FV^>vbۊyM-O|$ip9(Wf[ƕ? $
T
endstream
endobj
235 0 obj
<>>>/Subtype/Form>>stream
HVKn1@.UO # ayL"`bh4_E|?ݻ77t")#Igw~xc/L<pӣ'Tc`Ҡ8HdC
8RC ffE1IDFIa(zlTtf(4hE7PQkJIb31q '}Wp,u&fڤq1Fc:)"1liҘ`Hקol0Gذ*`vw!hIxV*2>.LoEcg*K@@'jЎ؈MLM%$FnzyclK)hP5MPD=^
`V'JΗ(>?VJ 1e1ffj9SW@b݂Pow[
V`%RARw!^dݷCA^MY D1-թ=:yЅ9^|ֿknq>ᚄdI\.yh'R-q9KGA:<&ejej/_> >5<8>eAo\Pk+gG3gN`;Y|?MԄ˱\_ž˯. j
endstream
endobj
369 0 obj
<>
endobj
241 0 obj
<>
endobj
239 0 obj
<>
endobj
237 0 obj
<>
endobj
380 0 obj
<>
endobj
238 0 obj
<>stream
H\j0~
C&0Z9 d6sOvKB/Sw )3>8%d|^& p-.Qh
%y%Sٯ)!#z3bfYCXy;0%Ǜ.X$&Zq_9Zӛ5ېOܫB6V
y)3xUx+{q0U` [q
endstream
endobj
403 0 obj
<>stream
HlU}PSW#y7SVXb,V|,Z
$`|4 RTiD*-EPXeEk Ղl(յtu[صy;{_LH9yL%(HK K40:MRcri3xLD*DޏQ}YW?G/I BE``[IŤjZmvSv+"!`3
rhv,Vj;[R"x0wH?aLA/8zѬ!d:mFa-!N&n4&n4:F[b2N-(0=f}@0wԓJRa0;MV(vD2(!-y LiB0d;J[H˖Q2\\7Ke[d~/YDo,MvBM1ꖗƫ
y[aRt+%t2]N.?h=z=SnWV)y'x7y'];G|/>53g|o_LLs3UUz)KȿK^Uşx
aa -܇nLHJ3,TbL<7F5hA-HяNn'%ϱPb(lp({J9թb2
P(WW :B,nD[O_Ž᳷U%8p|%-89OϢfAb"")ޱP5f6B>[Q1A{xmm=_d.w\sbn8(6"+}M
04+ G߯)o\qjKI:YeT=(@@9| X, ]]p{ux)t,TZUy
2PKthڏSIFțn1LG"ͭ)|c-}B"$]~AQ 瘑]6Pu4c\3bxjͥx~98-<3wH`rưJWGc+
Y<^?eij1כaI1&1QD[yKq7f+JoRJ n= I8tƙgþz#b|<Zu#2|ub6Z얤e\yjW~|D3N4=nnl.zmHcŃ`õ;3v8 fZq0GskG`s2`+!K\uZp<| -1oS1>#\G^=ȅ3tp:"0{0̿Fa( A
!\' fx6[>h"1U]$?IKtʈ]FI裒; B"?ľ=*f_XhREqtDExNŤ:D_GsQ[qhf
a8ذkcF!恆j5F)P
EfR<0I A et {PP!8Ǖt"z?P,y)R2/|)k*!W_|#>rx|W?
7ƽy*0L2"/ z*q
tjTn][r*H]M@H W-AAFE]H\LH>HWA!Ut.!
tJĿV U4D@wE5qb8S3m%/jC {ǒ7YY1> IO+~̼_盟%<8)C*ZSțV^ц@!&qe&
k>a{ Kz#>@1jC8][}<оl/v_[7HC'OHU<-&rQB&p%a~=ab+Ɩ=]l͆DF!^G#=iM0w<~RH
J[żuŝRJ]l#c,jݣ&ZIa{*&ʨ &?(|@~KyDuEaQ1Hf;%VZHղ"T
ʢA(KEUMdiA
"hJϣ&=o\bڤ?&ow;p8:61+[7e@^6q<lUAqUmndЮؠpu")?-_z2b >K'*XacvQKQKr Vxl
>P~\(
?ð4Z^N7w %Y s}{GޝSxwwv0'P-
(7@ 4{@%~!|`: xJ"QH̊0Llia=*[O99ltofj,wh7ƷsXnj:Gނ+xwss7C7T哘А|?rB; $K8|tބ(ca.@P0D+3QVni' d'ƄhU7l㙶SeiDF3_<"g@V1e}eV,lYYjdTJg|nVO]]sjS{q 0
WĶFhrwjK4XS]tXDo&%]lzA5u0+ѐDnK~،Kn܆YDd*ZB+0tCGKf:A#rx
adR- #L{QI\ޗXlvؿnf6$A&VD?D\Űb89㧘VP!KN)j.%Hcj6řB&4B"]M$a h`d]RdY,RnX5k}\/.̎JF-1XP9lIr@[7.ڰ&#ܽab1 jS(Q:bEԽpl~tˏ-uE?}]>ز>DKjax9D{ST&oS7 w'sMICJ'3wA,nC/{l!;9ـų)RU^;> pWaQ^ oଈaTí
=5K?b6;Hy4ʙp_̠G+Fgyv\U
G06DoDՑ\DydhL*{QL(9ځhYnp8-b6ä5RgE+VeEVk!Y\fTWR#͖/cU)jY:aݘK#lz`Ř1\OByLǘឌ#?70@0@QƣіLV35KP|x
ty!|g[LM z? pk
endstream
endobj
372 0 obj
<>
endobj
373 0 obj
<>
endobj
240 0 obj
<>stream
H\ϊ >C1 "a NRacĘC~G-]XA'3iϭeme^D
PZ.r-$ԚafB Z73:mF}7xZT(C(v _fS3rV^͈Ld4*WC!QvwLW*β:(Ecq|N|x#S >%>n7//ew:9O_Y!z\?eg
0 k~
endstream
endobj
405 0 obj
<>stream
HlS
PTU~o ŗ>
^IA.8Tn.]vYEXIpMV
sFq˙Fc,[6v'f3gν߹\S$INIKϜ!;ElzM,zez2Tb*"UHGH)я+O\GGjLED$NKe$4aN7SH
EA_nw%v!S2RlrR\,'Y3|IM$lEBU9KE!hq2+E`rQBfIGEEV8,1X͢0نidaEl[f&!L%ɂWP%(jIa6>]oقE," TBK舗tbMybT:3D1D@6UՐڠnV@xurhek 'mE`;4B X>CJP1^Qʂ;oi~ s'ZP$B>
Sg5vt1B3x?,MY#}Ά"n. v5yZiY4"ۨ)Nd.uE%9Ԝ5H&w~4@حd7X&4=4¨z_a'y59KUeJo3.2' }7JZE)H2DF
.2ضppL،c84XH:c;=cf|=p *_[4lM-r6w~T7]EZJq.]۳qOu5f}zÜ~Cm}ws[USBuJИyYŃӆcg>o~|c!YP>P }#p};e+%r&[}`"JPRGc%eY>L 1_4 yŶk-]EFF MWTocin"+*ZsJ(
hBŀ*~/~#ܕ$4BILͨ=jWٹ+BoZv;DWYYUνK
ҘAK.T4j
bhhQ<=|-f!G4<?@dd^'rlb` Z^p
endstream
endobj
367 0 obj
<>
endobj
242 0 obj
<>stream
H\݊0l/[`7)]XA13T,w;βukqV"e۫_54FN|YZws|i\xŵl7.k\z,
b~Ҙf@x٦ny?/\#6'(C2?I̲k+ðǡs\'1k" i9"c9!2o3xǼ#3K|p6%mʞSM=Eހ{\y `@8|'|2'B
ztZ&J>@ݭu#k|Nt*zů h
endstream
endobj
408 0 obj
<>stream
HlTPgaٕǢ;703"""( d`y겢xbĈEA1>b>!JAy
Ը69;nsvpY6/mix>7뵚$~
6bV`pY`hr^oxNBKޞ[!`2㾸jARE221U&}vPMBT.Zg\sB3_P%F*Icu\t~>7(L|!o*rlrl)3fqz\bD@yM8s- Tr"i:.-zQV^ˏlh91EkyY#"]cZh(/AS'
ӋBg_2>0(NPs:>kc錹{`Gca31l6r0(ouE^%awniSSSq~ǹҹ!+C}ik
+-(=5*h~Q|W5unV펹Ǻs.owz=tg=^=z迍:bLǘ)
JMNQMN⢜xVR,
'HD4
_0@"wHdf#Q'vڱBM.s%h|jXAN:߯TGDN7}YD,I=}v?ົŋO+r4owT&,f
{[l{W̸65EǏ)OV4ΰrE1/)uz@=jMj}rlW+}x?q䙖`WXvX{X&48C\py5?2T32hHQpoW"Hܬ-ɖɅWxw[I9뙏lvK0H*G4ZO3i3MGJҎ"laJd%
CB , hfٍ|(LH$߄`82yFCY/*#_rhxZ|I66'HyUExhO`MР:-FRC*4sJ5HxMj;L hh߂|-HZ`裮_jhj#ERVҐ/d^G+lvp]23IGexJķP/\+]OFgNQw
Hm`I:⣚Y1B~%L(r0tƂLmՠ!]=+Xu60bl%B][>(i6!3
C~{bHg!{m|k1듥Kmd.%tf$?ݟ.e)!q7;r^0ErBpNfN0 9&5_u