Association between developmental milestones and age of schizophrenia onset: results from the Northern Finland birth cohort 1966

Stochl, Jan, Whittier, Anjalene, Wagner, Adam, Veijola, Juha, Jääskeläinen, Erika, Miettunen, Jouko, Khandaker, Golam M and Jones, Peter B (2019) Association between developmental milestones and age of schizophrenia onset: results from the Northern Finland birth cohort 1966. Schizophrenia Research, 208. pp. 228-234. ISSN 0920-9964

[img]
Preview
PDF (Accepted_Manuscript) - Submitted Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview
[img]
Preview
PDF (Stochl_etal_2019_SR) - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

We investigated relationships between early developmental milestones, schizophrenia incidence and variability in its age at onset. We hypothesised that the period of risk for schizophrenia would be longer for those with later development. The Northern Finland Birth Cohort 1966 was followed until 47 years of age, and those members diagnosed with schizophrenia or any other non-affective psychoses identified. Latent profile analysis was used to classify people into homogenous classes with respect to developmental milestones, and subsequently survival analysis explored relationship between classes and age of schizophrenia onset. Results suggest that 4-classes (early, regular, late, and extra late developers) can be identified, but due to few cases in one class (n=93, <0.01% of 10 501), only 3 classes (early, regular, late) could be meaningfully compared. Schizophrenia incidence until 47 years of age differed systematically between classes: late developers had the highest cumulative incidence (2.39%); regular were intermediate (1.25%); and early developers had the lowest incidence (0.99%). However, age at onset and its variability was similar across classes, suggesting that our hypothesis of a wider 'window' for schizophrenia onset in late developers was not supported.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 21 Feb 2019 14:30
Last Modified: 26 Mar 2020 01:25
URI: https://ueaeprints.uea.ac.uk/id/eprint/69983
DOI: 10.1016/j.schres.2019.02.013

Actions (login required)

View Item View Item