A single fungal MAP kinase controls plant cell-to-cell invasion by the rice blast fungus

Sakulkoo, Wasin, Oses-Ruiz, Miriam, Garcia, Ely Oliveira, Soanes, Darren M., Littlejohn, George R., Hacker, Christian, Correia, Ana, Valent, Barbara and Talbot, Nicholas J. (2018) A single fungal MAP kinase controls plant cell-to-cell invasion by the rice blast fungus. Science, 359 (6382). pp. 1399-1403. ISSN 0036-8075

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Abstract

Blast disease destroys up to 30% of the rice crop annually and threatens global food security. The blast fungus Magnaporthe oryzae invades plant tissue with hyphae that proliferate and grow from cell to cell, often through pit fields, where plasmodesmata cluster. We showed that chemical genetic inhibition of a single fungal mitogen-activated protein (MAP) kinase, Pmk1, prevents M. oryzae from infecting adjacent plant cells, leaving the fungus trapped within a single plant cell. Pmk1 regulates expression of secreted fungal effector proteins implicated in suppression of host immune defenses, preventing reactive oxygen species generation and excessive callose deposition at plasmodesmata. Furthermore, Pmk1 controls the hyphal constriction required for fungal growth from one rice cell to the neighboring cell, enabling host tissue colonization and blast disease.

Item Type: Article
Uncontrolled Keywords: magnaporthe-oryzae,biotrophic invasion,protein-kinase,infection,grisea,plasmodesmata,disease
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Depositing User: LivePure Connector
Date Deposited: 15 Feb 2019 11:30
Last Modified: 22 Apr 2020 07:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/69942
DOI: 10.1126/science.aaq0892

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