Bacterial Flagellins: Does Size Matter?

Thomson, Nicholas M., Rossmann, Florian M., Ferreira, Josie L., Matthews-Palmer, Teige R., Beeby, Morgan and Pallen, Mark J. ORCID: (2018) Bacterial Flagellins: Does Size Matter? Trends in Microbiology, 26 (7). pp. 575-581. ISSN 0966-842X

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The bacterial flagellum is the principal organelle of motility in bacteria. Here, we address the question of size when applied to the chief flagellar protein flagellin and the flagellar filament. Surprisingly, nature furnishes multiple examples of ‘giant flagellins’ greater than a thousand amino acids in length, with large surface-exposed hypervariable domains. We review the contexts in which these giant flagellins occur, speculate as to their functions, and highlight the potential for biotechnology to build on what nature provides.

Item Type: Article
Uncontrolled Keywords: bacterial flagellum,evolution,flagellin,surface display
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Depositing User: LivePure Connector
Date Deposited: 01 Feb 2019 14:30
Last Modified: 22 Oct 2022 04:27
DOI: 10.1016/j.tim.2017.11.010

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