The multifaceted roles of perlecan in fibrosis

Lord, Megan S., Tang, Fengying, Rnjak-Kovacina, Jelena, Smith, James, Melrose, James and Whitelock, John M. (2018) The multifaceted roles of perlecan in fibrosis. Matrix Biology, 68-69. pp. 150-166. ISSN 0945-053X

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Abstract

Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion. In this review, its roles in fibrosis are reviewed by drawing upon evidence from tissue and organ systems that undergo fibrosis as a result of an uncontrolled response to either inflammation or traumatic cellular injury leading to an over production of a collagen-rich extracellular matrix. This review focuses on examples of fibrosis that occurs in lung, liver, kidney, skin, kidney, neural tissues and blood vessels and its link to the expression of perlecan in that particular organ system.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 10 Jan 2019 11:30
Last Modified: 22 Apr 2020 07:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/69525
DOI: 10.1016/j.matbio.2018.02.013

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