An Organoiron Approach towards the Enantioselective Synthesis of Hippeastrine

Delf, Sarah (2017) An Organoiron Approach towards the Enantioselective Synthesis of Hippeastrine. Doctoral thesis, University of East Anglia.

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Abstract

This thesis describes work towards an organoiron approach towards the enantioselective synthesis of the alkaloid hippeastrine, starting from enantiomerically defined arene cis diols that can be made by biodioxygenation. Literature reviews of the target class of alkaloids, biodioxygenation, and the stereocontrolled applications of cationic electrophilic pentahapto cyclohexadienylium complexes, and the description of original work on biodioxygenation using R eutropha, and a series of new studies of complexation, activation, and nucleophile addition reactions using the organoiron approach are presented, supported by an Experimental Section to provide details of experimental procedures and compound characterisation.

Item Type: Thesis (Doctoral)
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Megan Ruddock
Date Deposited: 19 Dec 2018 12:14
Last Modified: 19 Dec 2021 01:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/69365
DOI:

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