Protein–protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics

Carro, Laura (2018) Protein–protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics. Beilstein Journal of Organic Chemistry, 14. pp. 2881-2896. ISSN 1860-5397

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Abstract

Antibiotics are potent pharmacological weapons against bacterial infections; however, the growing antibiotic resistance of microorganisms is compromising the efficacy of the currently available pharmacotherapies. Even though antimicrobial resistance is not a new problem, antibiotic development has failed to match the growth of resistant pathogens and hence, it is highly critical to discover new anti-infective drugs with novel mechanisms of action which will help reducing the burden of multidrug-resistant microorganisms. Protein–protein interactions (PPIs) are involved in a myriad of vital cellular processes and have become an attractive target to treat diseases. Therefore, targeting PPI networks in bacteria may offer a new and unconventional point of intervention to develop novel anti-infective drugs which can combat the ever-increasing rate of multidrug-resistant bacteria. This review describes the progress achieved towards the discovery of molecules that disrupt PPI systems in bacteria for which inhibitors have been identified and whose targets could represent an alternative lead discovery strategy to obtain new anti-infective molecules.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 07 Dec 2018 16:30
Last Modified: 18 Mar 2020 02:19
URI: https://ueaeprints.uea.ac.uk/id/eprint/69222
DOI: 10.3762/bjoc.14.267

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