A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets

Hemming, Ryan A., Bell, Megan, Duffy, Liam J., Bristow, Jonathan, Wallis, John D., Allin, Steven M. and Bulman Page, Philip C. (2019) A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets. Tetrahedron, 75 (1). pp. 121-127. ISSN 0040-4020

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Abstract

A new, versatile and highly stereoselective approach for the synthesis of non-racemic 3-substituted isoindolin-1-ones is described from a readily available chiral template. The potential of this new protocol is demonstrated through the synthesis of an enantiomerically enriched 3-alkyl N-H isoindolin-1-one target with an e.e. of 98%.

Item Type: Article
Uncontrolled Keywords: isoindolinone,n-acyliminium,stereoselective synthesis,biochemistry,drug discovery,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School: Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 27 Nov 2018 10:30
Last Modified: 20 Aug 2020 00:19
URI: https://ueaeprints.uea.ac.uk/id/eprint/69046
DOI: 10.1016/j.tet.2018.11.050

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