Myint, Phyo Kyaw, Wilson, Andrew M., Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Luben, Robert N., Wareham, Nicholas J. and Khaw, Kay-Tee
(2019)
Plasma vitamin C concentrations and risk of incident respiratory diseases and mortality in the European Prospective Investigation into Cancer-Norfolk Cohort.
European Journal of Clinical Nutrition, 73 (11).
1492–1500.
ISSN 0954-3007
Preview |
PDF (Accepted_manuscript)
- Accepted Version
Available under License Other licence. Download (888kB) | Preview |
![]() |
Microsoft Word (Myint et al-vit C-Ms R1 REVISED clean version)
- Draft Version
Download (67kB) |
Abstract
Background/Objectives: Cancerous and non-cancerous respiratory diseases are common and contribute significantly to global disease burden. We aim to quantify the association between plasma vitamin C concentrations as an indicator of high fruit and vegetable consumption and the risk of incident respiratory diseases and associated mortality in a general population. Subjects/Methods: Nineteen thousand three hundred and fifty-seven men and women aged 40–79 years without prevalent respiratory diseases at the baseline (1993–1997) and participating in the European Prospective Investigation into Cancer (EPIC)-Norfolk study in the United Kingdom were followed through March 2015 for both incidence and mortality from respiratory diseases. Results: There were a total of 3914 incident events and 407 deaths due to any respiratory diseases (excluding lung cancers), 367 incident lung cancers and 280 lung cancer deaths during the follow-up (total person-years >300,000 years). Cox's proportional hazards models showed that persons in the top quartiles of baseline plasma vitamin C concentrations had a 43% lower risk of lung cancer (hazard ratio (HR) 0.57; 95% confidence interval (CI): 0.41–0.81) than did those in the bottom quartile, independently of potential confounders. The results are similar for any non-cancerous respiratory diseases (HR 0.85; 0.77–0.95), including chronic respiratory diseases (HR 0.81; 0.69–0.96) and pneumonia (HR 0.70; 0.59–0.83). The corresponding values for mortality were 0.54 (0.35–0.81), 0.81 (0.59–1.12), 0.85 (0.44–1.66) and 0.61 (0.37–1.01), respectively. Confining analyses to non-smokers showed 42% and 53% risk reduction of non-smoking-related lung cancer incidence and death. Conclusions: Higher levels of vitamin C concentrations as a marker of high fruit and vegetable consumption reduces the risk of cancerous and non-cancerous respiratory illnesses including non-smoking-related cancer incidence and deaths.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
Related URLs: | |
Depositing User: | LivePure Connector |
Date Deposited: | 23 Nov 2018 15:30 |
Last Modified: | 22 Oct 2022 04:18 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/69019 |
DOI: | 10.1038/s41430-019-0393-1 |
Actions (login required)
![]() |
View Item |