The relationships between age, associative memory performance, and the neural correlates of successful associative memory encoding

de Chastelaine, Marianne, Mattson, Julia T., Wang, Tracy H., Donley, Brian E. and Rugg, Michael D. (2016) The relationships between age, associative memory performance, and the neural correlates of successful associative memory encoding. Neurobiology of Aging, 42. pp. 163-176. ISSN 0197-4580

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Abstract

Using functional magnetic resonance imaging, subsequent memory effects (greater activity for later remembered than later forgotten study items) predictive of associative encoding were compared across samples of young, middle-aged, and older adults (total N = 136). During scanning, participants studied visually presented word pairs. In a later test phase, they discriminated between studied pairs, “rearranged” pairs (items studied on different trials), and new pairs. Subsequent memory effects were identified by contrasting activity elicited by study pairs that went on to be correctly judged intact or incorrectly judged rearranged. Effects in the hippocampus were age-invariant and positively correlated across participants with associative memory performance. Subsequent memory effects in the right inferior frontal gyrus (IFG) were greater in the older than the young group. In older participants only, both left and, in contrast to prior reports, right IFG subsequent memory effects correlated positively with memory performance. We suggest that the IFG is especially vulnerable to age-related decline in functional integrity and that the relationship between encoding-related activity in right IFG and memory performance depends on the experimental context.

Item Type: Article
Uncontrolled Keywords: fmri,aging,associative recognition,episodic memory,hippocampus,over-recruitment
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Depositing User: LivePure Connector
Date Deposited: 13 Nov 2018 15:30
Last Modified: 22 Apr 2020 07:13
URI: https://ueaeprints.uea.ac.uk/id/eprint/68869
DOI: 10.1016/j.neurobiolaging.2016.03.015

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