CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

Hems, Edward S., Wagstaff, Ben A., Saalbach, Gerhard and Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275 (2018) CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins. Chemical Communications, 54 (86). pp. 12234-12237. ISSN 1359-7345

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Abstract

In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Science > Research Groups > Synthetic and Medicinal Chemistry
Related URLs:	http://xlink.rsc.org/?DOI=C8CC05113E
Depositing User:	LivePure Connector
Date Deposited:	25 Oct 2018 15:30
Last Modified:	18 Jun 2026 17:58
URI:	https://ueaeprints.uea.ac.uk/id/eprint/68638
DOI:	10.1039/C8CC05113E

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