CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

Hems, Edward S., Wagstaff, Ben A., Saalbach, Gerhard and Field, Robert A. (2018) CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins. Chemical Communications, 54 (86). pp. 12234-12237. ISSN 1359-7345

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Abstract

In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 25 Oct 2018 15:30
Last Modified: 28 Jul 2020 23:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/68638
DOI: 10.1039/C8CC05113E

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