Muravev, Anton A., Solovieva, Svetlana E., Galieva, Farida B., Bazanova, Olga B., Rizvanov, Ildar Kh., Ivshin, Kamil A., Kataeva, Olga N., Matthews, Susan E. and Antipin, Igor S. (2018) Calixarene alpha-ketoacetylenes: versatile platforms for reaction with hydrazine nucleophile. RSC Advances, 8 (57). pp. 32765-32769. ISSN 2046-2069

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Abstract

Late stage diversification of calix[4]arenes and thiacalix[4]arenes with heterocycles remains a significant synthetic challenge and hampers further exploitation of the scaffolds. Here we describe the development of a short and facile synthetic route to conformationally diverse novel calix[4]arene and thiacalix[4]arene ynones using a palladium cross coupling approach (5% Pd(II) + 10% Cu(I)) with benzoyl chloride. Their successful conversion to heterocycles to afford pyrazoles was demonstrated through treatment with hydrazine. Functionalisation is calixarene conformation and linker independent enabling access to a library of structures.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	http://xlink.rsc.org/?DOI=C8RA06349D
Depositing User:	LivePure Connector
Date Deposited:	12 Oct 2018 09:30
Last Modified:	22 Apr 2020 07:06
URI:	https://ueaeprints.uea.ac.uk/id/eprint/68489
DOI:	10.1039/C8RA06349D

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