Long term effectiveness of electrochemotherapy for the treatment of lower lip squamous cell carcinoma

Gargiulo, M., Serra Mestre, J.M., Cortese, A., Murphy, D.C., Parascandolo, S. and Razzano, S. (2018) Long term effectiveness of electrochemotherapy for the treatment of lower lip squamous cell carcinoma. Journal of Cranio-Maxillofacial Surgery, 46 (11). pp. 1968-1974. ISSN 1010-5182

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Abstract

Purpose: Electrochemotherapy (ECT) is a therapeutic approach based on the local application of electrical pulses that permeabilize cell membranes to enhance the uptake of low-permeant chemotherapeutic agents, thus increasing their cytotoxic effects. Materials and Methods: Twenty-one patients with SCC of the lower lip were treated according to the European Standard Operating Procedures of Electrochemotherapy. Bleomycin (15,000 IU/m2 body surface area) was administered intravenously over a 1-minute period. Eight electrical pulses (amplitude, 1000 V/cm; duration, 100 μs) were generated and delivered at a repetition frequency of 5 kHz. Changes in tumor volume were used to assess treatment response. Results: Objective response (OR), complete response (CR), and partial response (PR) rates of 100%, 71.4%, and 28.6% respectively were demonstrated following a single session of ECT. ECT was well tolerated, and no adverse events occurred. Conclusions: Intravenous bleomycin-based ECT is a safe and effective therapy for SCC of the lower lip. ECT improves the quality-of-life of patients by preserving the function and the aesthetic appearance of the affected area. ECT provides a therapeutic option for elderly and frail patients who, due to their state of health, are not suitable for, or refuse surgical interventions.

Item Type: Article
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 04 Sep 2018 09:32
Last Modified: 30 Apr 2020 23:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/68190
DOI: 10.1016/j.jcms.2018.08.013

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