The challenges of stratifying patients for trials in inflammatory bowel disease

Biancheri, Paolo, Powell, Nick, Monteleone, Giovanni, Lord, Graham and MacDonald, Thomas T (2013) The challenges of stratifying patients for trials in inflammatory bowel disease. Trends in Immunology, 34 (11). pp. 564-571. ISSN 1471-4906

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Abstract

Immunotherapy with biological agents or small molecules is revolutionising the treatment of chronic inflammatory disease in humans; however, a significant proportion of patients fail to respond or lose responsiveness. This is particularly evident in inflammatory bowel disease (IBD), a group of chronic, immune-mediated disorders of the gastrointestinal tract. Different responsiveness to treatment in IBD can be explained by substantial disease heterogeneity, which is being increasingly recognised by genetic and immunological studies. The current enthusiasm for stratified medicine suggests that it may become possible to identify clinical, immunological, biochemical or genetic biomarkers to target immunotherapy to patients more likely to respond. Here, we identify and highlight the opportunities and the challenges of this strategy in the context of IBD.

Item Type: Article
Additional Information: Copyright © 2013 Elsevier Ltd. All rights reserved.
Uncontrolled Keywords: metabolism,humans,methods,immunology
Depositing User: LivePure Connector
Date Deposited: 07 Aug 2018 16:30
Last Modified: 22 Apr 2020 06:56
URI: https://ueaeprints.uea.ac.uk/id/eprint/67980
DOI: 10.1016/j.it.2013.08.002

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