The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

Biancheri, Paolo, Giuffrida, Paolo, Docena, Guillermo H, MacDonald, Thomas T, Corazza, Gino Roberto and Di Sabatino, Antonio (2014) The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut. Cytokine & Growth Factor Reviews, 25 (1). pp. 45-55. ISSN 1359-6101

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Abstract

Transforming growth factor (TGF)-β, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-β also enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-β signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-β signaling in chronic intestinal diseases.

Item Type: Article
Additional Information: Copyright © 2013 Elsevier Ltd. All rights reserved.
Uncontrolled Keywords: animals,physiology,humans,drug effects,immunology,immunology,immunology,mice,physiology,physiology,physiology,wound healing
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 07 Aug 2018 16:30
Last Modified: 22 Apr 2020 06:56
URI: https://ueaeprints.uea.ac.uk/id/eprint/67979
DOI: 10.1016/j.cytogfr.2013.11.001

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