Normalized perfusion MRI to identify common areas of dysfunction:Patients with basal ganglia neglect

Karnath, Hans-Otto, Zopf, Regine, Johannsen, Leif ORCID:, Berger, Monika Fruhmann, Nägele, Thomas and Klose, Uwe (2005) Normalized perfusion MRI to identify common areas of dysfunction:Patients with basal ganglia neglect. Brain, 128 (10). pp. 2462-2469. ISSN 0006-8950

Full text not available from this repository.


Perfusion-weighted imaging (PWI) is used to identify brain regions that are receiving enough blood supply to remain structurally intact, but not enough to function normally. Previous observations suggest that spatial neglect due to subcortical stroke can be explained by dysfunction of cortical areas rather than through the neuronal loss in the subcortical structures itself. The present study aimed to identify the dysfunctional cortical regions induced by basal ganglia stroke in patients with spatial neglect. In a patient group with stroke lesions centring on the basal ganglia, we examined the common area(s) of structurally intact but dysfunctional cortical tissue by using spatial normalization of PWI maps as well as symmetric voxel-wise inter-hemispheric comparisons. These new techniques allow comparison of the structurally intact but abnormally perfused areas of different individuals in the same stereotaxic space, and at the same time avoid problems due to regional perfusion differences and to possible observer-dependent biases. We found that strokes centring on the right basal ganglia which provoke spatial neglect induce abnormal perfusion in a circumscribed area of intact cortex that typically involves those three regions that have previously been described to provoke spatial neglect when damaged directly by cortical infarction: the superior temporal gyrus, the inferior parietal lobule and the inferior frontal gyrus. The data suggest that spatial neglect following a right basal ganglia lesion typically is caused by the dysfunction of (part of) these specific cortical areas.

Item Type: Article
Uncontrolled Keywords: attention,basal ganglia,exploration,human,perfusion-weighted imaging,spatial neglect,visual search,clinical neurology ,/dk/atira/pure/subjectarea/asjc/2700/2728
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 23 Jul 2018 09:30
Last Modified: 22 Oct 2022 04:00
DOI: 10.1093/brain/awh629

Actions (login required)

View Item View Item