The hippocampal longitudinal axis – relevance for underlying tau and TDP-43 pathology?

Llado, Albert, Tort-Merino, Adrià, Sanchez-Valle, Raquel, Falgas, Neus, Balasa, Mircea, Bosch, Bea, Castellvi, Magda, Olives, Jaume, Antonell, Anna and Hornberger, Michael (2018) The hippocampal longitudinal axis – relevance for underlying tau and TDP-43 pathology? Neurobiology of Aging, 73. pp. 1-9. ISSN 0197-4580

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Abstract

Recent studies suggest that hippocampus has different cortical connectivity and functionality along its longitudinal axis. We sought to elucidate the possible different pattern of atrophy in longitudinal axis of hippocampus between Amyloid/Tau pathology and TDP-43-pathies. Seventy-three presenile subjects were included: Amyloid/Tau group (33 Alzheimer’s disease (AD) with confirmed CSF biomarkers), probable TDP-43 group (7 semantic variant progressive primary aphasia, 5 GRN and 2 C9orf72 mutation carriers) and 26 healthy controls. We conducted a region-of-interest voxel-based morphometry analysis on the hippocampal longitudinal axis, by contrasting the groups, covarying with CSF biomarkers (Aβ42, total tau, p-tau) and covarying with episodic memory scores. Amyloid/Tau pathology affected mainly posterior hippocampus while anterior left hippocampus was more atrophied in probable TDP-43pathies. We also observed a significant correlation of posterior hippocampal atrophy with AD CSF biomarkers and visual memory scores. Taken together, these data suggest that there is a potential differentiation along the hippocampal longitudinal axis based on the underlying pathology, which could be used as a potential biomarker to identify the underlying pathology in different neurodegenerative diseases.

Item Type: Article
Uncontrolled Keywords: alzheimer’s disease,tau,tdp-43,mri,semantic variant of progressive primary aphasia,frontotemporal dementia,memory,hippocampus
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 19 Jun 2018 13:30
Last Modified: 20 Sep 2020 23:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/67396
DOI: 10.1016/j.neurobiolaging.2018.05.035

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