Carotid atherosclerosis detected by ultrasonography: A national cross-sectional study

Wang, Xiaojun, Li, Wenzhen, Song, Fujian, Wang, Longde, Fu, Qian, Cao, Shiyi, Gan, Yong, Zhang, Wei, Yue, Wei, Yan, Feng, Shi, Wenhuan, Zhang, Xaoli, Zhang, Hong, Zhang, Hao, Wang, Zhihong and Lu, Zuxun (2018) Carotid atherosclerosis detected by ultrasonography: A national cross-sectional study. Journal of the American Heart Association, 7 (8). ISSN 2047-9980

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Background: Carotid atherosclerosis (CA) is a reflector of generalized atherosclerosis that is associated with systemic vascular disease. Data are limited on the epidemiology of carotid lesions in a large, nationally representative population sample. We aimed to evaluate the prevalence of CA detected by carotid ultrasonography and related risk factors based on a national survey in China. Methods and Results: A total of 107 095 residents aged ≥40 years from the China National Stroke Prevention Project underwent carotid ultrasound examination. Participants with carotid endarterectomy or carotid stenting and those with stroke or coronary heart disease were excluded. Data from 84 880 participants were included in the analysis. CA was defined as increased intima–media thickness (IMT) ≥1 mm or presence of plaques. Of the 84 880 participants, 46.4% were men, and the mean age was 60.7±10.3 years. The standardized prevalence of CA was 36.2% overall, increased with age, and was higher in men than in women. Prevalence of CA was higher among participants living in rural areas than in urban areas. Approximately 26.5% of participants had increased IMT, and 13.9% presented plaques. There was an age‐related increase in participants with increased IMT, plaque presence, and stenosis. In multiple logistic regression analysis, older age, male sex, residence in rural areas, smoking, alcohol consumption, physical inactivity, obesity, hypertension, diabetes mellitus, and dyslipidemia were associated with CA. Conclusions: CA was highly prevalent in a middle‐aged and older Chinese population. This result shows the potential clinical importance of focusing on primary prevention of atherosclerosis progression.

Item Type: Article
Uncontrolled Keywords: atherosclerosis,carotid ultrasound,china,epidemiology,risk factor,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care
Faculty of Medicine and Health Sciences > Research Centres > Population Health
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Depositing User: Pure Connector
Date Deposited: 30 Apr 2018 10:30
Last Modified: 05 Apr 2024 00:30
DOI: 10.1161/JAHA.118.008701


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