Quality of life among hazardous and harmful drinkers:EQ-5D over a 1-year follow-up period

Essex, Holly N, White, Ian R, Khadjesari, Zarnie, Linke, Stuart, McCambridge, Jim, Murray, Elizabeth, Parrott, Steve and Godfrey, Christine (2014) Quality of life among hazardous and harmful drinkers:EQ-5D over a 1-year follow-up period. Quality of Life Research, 23 (2). pp. 733-743. ISSN 0962-9343

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Abstract

PURPOSE: To investigate the ability of the EQ-5D to discriminate between levels of alcohol risk in a large sample of hazardous and harmful drinkers, and to explore the relationship between transitions between alcohol risk levels and changes in EQ-5D up to 12 months.  METHODS: This is a web-based randomised controlled trial evaluating a novel intervention for hazardous and harmful alcohol consumption. EQ-5D scores were compared among groups of drinkers at baseline (low/medium/high risk according to self-reported past week alcohol consumption), and changes in EQ-5D scores were estimated as a function of changes in alcohol consumption level.  RESULTS: Baseline EQ-5D scores were dominated by problems with anxiety/depression, which increased with alcohol risk level, whilst high-risk drinkers also experienced more problems with physical HRQoL dimensions. However, the tool demonstrated a considerable ceiling effect. At follow-up, despite considerable reductions in alcohol consumption across the sample, significant changes in aggregated EQ-5D index scores were only observed for high-risk drinkers at baseline who reduced their drinking, with small improvements (0.04-0.06) compared to those who did not reduce.  CONCLUSIONS: Our results suggest that the three-option EQ-5D may not be an optimal primary end point for measuring clinical and cost-effectiveness in randomised controlled trials of interventions among hazardous and harmful alcohol users, although further testing of the sensitivity of the tool in these populations is needed.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Depositing User: Pure Connector
Date Deposited: 09 Apr 2018 16:30
Last Modified: 22 Apr 2020 06:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/66716
DOI: 10.1007/s11136-013-0521-7

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