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Tse, Gary, Gong, Mengqi, Meng, Lei, Wong, Cheuk Wai, Georgopoulos, Stamatis, Bazoukis, George, Wong, Martin C. S., Letsas, Konstantinos P., Vassiliou, Vassilios S. 
ORCID: https://orcid.org/0000-0002-4005-7752, Xia, Yunlong, Baranchuk, Adrian M., Yan, Gan-Xin and Liu, Tong
(2018)
Meta-analysis of Tpeak –Tend and Tpeak –Tend /QT ratio for risk stratification in congenital long QT syndrome.
Journal of Electrocardiology, 51 (3).
pp. 396-401.
ISSN 0022-0736
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Abstract
Background and objectives: Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death. The Tpeak–Tend interval and the Tpeak–Tend/QT ratio, electrocardiographic markers of dispersion of ventricular repolarization, were proposed for risk stratification but their predictive values in LQTS have been controversial. A systematic review and meta-analysis was conducted to examine the value of Tpeak–Tend intervals and Tpeak–Tend/QT ratios in predicting arrhythmic and mortality outcomes in congenital LQTS. Method: PubMed and Embase databases were searched until 9th May 2017, identifying 199 studies. Results: Five studies on long QT syndrome were included in the final meta-analysis. Tpeak–Tend intervals were longer (mean difference [MD]: 13 ms, standard error [SE]: 4 ms, P = 0.002; I2 = 34%) in congenital LQTS patients with adverse events [syncope, ventricular arrhythmias or sudden cardiac death] compared to LQTS patients without such events. By contrast, Tpeak–Tend/QT ratios were not significantly different between the two groups (MD: 0.02, SE: 0.02, P = 0.26; I2 = 0%). Conclusion: This meta-analysis showed that Tpeak–Tend interval is significant higher in individuals who are at elevated risk of adverse events in congenital LQTS, offering incremental value for risk stratification.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 26 Mar 2018 12:30 |
| Last Modified: | 19 Oct 2023 02:09 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/66596 |
| DOI: | 10.1016/j.jelectrocard.2018.03.001 |
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