Confinement of carbon dots localizing to the ultrathin layered double hydroxides toward simultaneous triple-mode bioimaging and photothermal therapy

Weng, Yangziwan, Guan, Shanyue, Lu, Heng, Meng, Xiangmin, Kaassis, Abdessamad. Y, Ren, Xiaoxue, Qu, Xiaozhong, Sun, Chenghua, Xie, Zheng and Zhou, Shuyun (2018) Confinement of carbon dots localizing to the ultrathin layered double hydroxides toward simultaneous triple-mode bioimaging and photothermal therapy. Talanta, 184. pp. 50-57. ISSN 0039-9140

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Abstract

It is a great challenge to develop multifunctional nanocarriers for cancer diagnosis and therapy. Herein, versatile CDs/ICG-uLDHs nanovehicles for triple-modal fluorescence/photoacoustic/two-photon bioimaging and effective photothermal therapy were prepared via a facile self-assembly of red emission carbon dots (CDs), indocyanine green (ICG) with the ultrathin layered double hydroxides (uLDHs). Due to the J-aggregates of ICG constructed in the self-assembly process, CDs/ICG-uLDHs was able to stabilize the photothermal agent ICG and enhanced its photothermal efficiency. Furthermore, the unique confinement effect of uLDHs has extended the fluorescence lifetime of CDs in favor of bioimaging. Considering the excellent in vitro and in vivo phototherapeutics and multimodal imaging effects, this work provides a promising platform for the construction of multifunctional theranostic nanocarrier system for the cancer treatment.

Item Type: Article
Uncontrolled Keywords: carbon dots,ultrathin layered double hydroxides,triple-mode imaging photothermal therapy
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: Pure Connector
Date Deposited: 02 Mar 2018 11:30
Last Modified: 13 Oct 2019 00:34
URI: https://ueaeprints.uea.ac.uk/id/eprint/66413
DOI: 10.1016/j.talanta.2018.02.093

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