[6S]5-methyltetrahydrofolate or folic acid supplementation and absorption and initial elimination of folate in young and middle-aged adults

de Meer, K, Smulders, Y M, Dainty, J R ORCID: https://orcid.org/0000-0002-0056-1233, Smith, D E C, Kok, R M, Stehouwer, C D A, Finglas, P M and Jakobs, C (2005) [6S]5-methyltetrahydrofolate or folic acid supplementation and absorption and initial elimination of folate in young and middle-aged adults. European Journal of Clinical Nutrition, 59. pp. 1409-1416. ISSN 0954-3007

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Objectives: To assess the effects of supplementation with the diastereoisomer of 5-methyltetrahydrofolate ([6S]5-methylTHF), as an alternative supplement for folic acid, on folate absorption and elimination, in two age groups. Design: A randomized, double-blind intervention study. Subjects: A total of 12 young (<30 y) and 12 middle-aged (≥50 y) healthy volunteers were recruited. Methods: Volunteers were randomized to receive daily supplementation with 400 μg folic acid or equimolar amounts of [6S]5-methylTHF during 5 weeks. Before and after supplementation, absorption and initial elimination were calculated following oral [2H2]folic acid test doses using isotope kinetics in plasma. Results: Folic acid absorption was lower in the middle-aged as compared to the young adults, both before (P=0.03) and after (P=0.05) supplementation. In the young adults, absorption decreased by 22% after [6S]5-methylTHF and increased by 21% after folic acid (P=0.02). In the other age group, no such changes were found. The folate rate constant of elimination increased after folic acid supplementation in the young (+50%; P=0.05) but not in the middle-aged (+18%; P=0.5) adults. Conclusions: Young adults show increased folate turnover after folic acid supplementation relative to the effect of [6S]5-methylTHF supplementation. Similar differences are not observed in middle-aged adults, in whom folic acid absorption was found to be lower as compared to the young adults.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Population Health
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Depositing User: Pure Connector
Date Deposited: 27 Feb 2018 15:30
Last Modified: 06 Jun 2024 15:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/66388
DOI: 10.1038/sj.ejcn.1602254

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