Urinary excretion of strawberry anthocyanins is dose dependent for physiological oral doses of fresh fruit

Hollands, Wendy, Brett, Gary M., Dainty, Jack R. ORCID: https://orcid.org/0000-0002-0056-1233, Teucher, Birgit and Kroon, Paul A. (2008) Urinary excretion of strawberry anthocyanins is dose dependent for physiological oral doses of fresh fruit. Molecular Nutrition & Food Research, 52 (10). pp. 1097-1105. ISSN 1613-4125

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There is considerable interest in coloured fruits and berries as sources of biologically active anthocyanins. To examine the relationship between the oral dose and the amount excreted for anthocyanins from a food source across a physiological range of doses, volunteers were fed, in random order, four portions (100–400 g) of fresh strawberries as part of a standard breakfast. Urine was collected at 2 h intervals up to 8 h, and for the period 8–24 h. Fresh strawberries contained pelargonidin-3-glucoside as the major anthocyanin with smaller amounts of cyanidin-3-glucoside and pelargonidin-3-rutinoside. Anthocyanins were detected in the urine of all volunteers for all doses, predominantly as pelargonidin glucuronide and sulphate metabolites. There was a strong, linear relationship between oral dose and anthocyanin excretion (Pearson's product moment correlation coefficient = 0.692, p < 0.001, n = 40) which indicated that on an average, every additional unit of dose caused 0.0166 units of excretion. Within individuals, dose – excretion data fitted a linear regression model (median R2 = 0.93). We conclude that strawberry anthocyanins are partially bioavailable in humans with a linear relationship between oral dose and urinary excretion for doses up to 400 g fresh fruit.

Item Type: Article
Uncontrolled Keywords: bioavailability,dietary antioxidants,flavonoids,human metabolism,polyphenols
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
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Depositing User: Pure Connector
Date Deposited: 26 Feb 2018 17:30
Last Modified: 22 Oct 2022 03:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/66382
DOI: 10.1002/mnfr.v52:10

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