Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials

Tools

Armah, Charlotte N., Derdemezis, Christos, Traka, Maria H., Dainty, Jack R. ORCID: https://orcid.org/0000-0002-0056-1233, Doleman, Joanne F., Saha, Shikha, Leung, Wing, Potter, John F., Lovegrove, Julie A. and Mithen, Richard F. (2015) Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials. Molecular Nutrition & Food Research, 59 (5). pp. 918-926. ISSN 1613-4125

[thumbnail of Published manuscript]
Preview
 PDF (Published manuscript) - Published Version
Available under License Creative Commons Attribution.
Download (245kB) | Preview

Abstract

Scope: Cruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables. This study tests the hypothesis that a diet rich in high glucoraphanin (HG) broccoli will reduce plasma LDL-C. Methods and results: One hundred and thirty volunteers were recruited to two independent double-blind, randomly allocated parallel dietary intervention studies, and were assigned to consume either 400 g standard broccoli or 400 g HG broccoli per week for 12 weeks. Plasma lipids were quantified before and after the intervention. In study 1 (37 volunteers), the HG broccoli diet reduced plasma LDL-C by 7.1% (95% CI: –1.8%, –12.3%, p = 0.011), whereas standard broccoli reduced LDL-C by 1.8% (95% CI +3.9%, –7.5%, ns). In study 2 (93 volunteers), the HG broccoli diet resulted in a reduction of 5.1% (95% CI: –2.1%, –8.1%, p = 0.001), whereas standard broccoli reduced LDL-C by 2.5% (95% CI: +0.8%, –5.7%, ns). When data from the two studies were combined the reduction in LDL-C by the HG broccoli was significantly greater than standard broccoli (p = 0.031). Conclusion: Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.

Item Type: Article
Uncontrolled Keywords: broccoli,cholesterol,glucoraphanin,sulforaphane
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: Pure Connector
Date Deposited: 26 Feb 2018 15:30
Last Modified: 22 Oct 2022 03:35
URI: https://ueaeprints.uea.ac.uk/id/eprint/66371
DOI: 10.1002/mnfr.v59.5

Actions (login required)

View Item View Item