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Coughlan, Gillian, Flanagan, Emma, Jeffs, Stephen 
ORCID: https://orcid.org/0000-0003-1122-1012, Bertoux, Maxime, Spiers, Hugo, Mioshi, Eneida and Hornberger, Michael ORCID: https://orcid.org/0000-0002-2214-3788
(2018)
Diagnostic relevance of spatial orientation for vascular dementia: A case study.
Dementia & Neuropsychologia, 12 (1).
pp. 85-91.
ISSN 1980-5764
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Abstract
Background: Spatial orientation is emerging as an early and reliable cognitive biomarker of Alzheimer’s disease (AD) pathophysiology. However, no evidence exists as to whether spatial orientation is also affected in vascular dementia (VaD). Objective: To examine allocentric (map-based) and egocentric (viewpoint-based) spatial orientation in an early stage VaD case. Methods: A spatial test battery was administered following clinical and neuropsychological cognitive evaluation. Results: Despite the patient’s complaints, little evidence of episodic memory deficits were detected when cueing was provided to overcome executive dysfunction. Similarly, medial temporal lobe-mediated allocentric orientation was intact. By contrast, medial parietal-mediated egocentric orientation was impaired, despite normal performance on standard visuospatial tasks. Conclusion: To our knowledge, this is the first in-depth investigation of spatial orientation deficits in VaD. Isolated egocentric deficits were observed. This differs from AD orientation deficits which encompass both allocentric and egocentric orientation deficits. A combination of egocentric orientation and executive function tests could serve as a promising cognitive marker for VaD pathophysiology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | spatial orientation,egocentric,allocentric,vascular dementia,vad,executive function,neurodegeneration |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Social Sciences > School of Psychology Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 12 Feb 2018 10:30 |
| Last Modified: | 11 Jan 2024 01:31 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/66264 |
| DOI: | 10.1590/1980-57642018dn12-010013 |
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