Diagnostic relevance of spatial orientation for vascular dementia: A case study

Coughlan, Gillian, Flanagan, Emma, Jeffs, Stephen, Bertoux, Maxime, Spiers, Hugo, Mioshi, Eneida and Hornberger, Michael (2018) Diagnostic relevance of spatial orientation for vascular dementia: A case study. Dementia & Neuropsychologia, 12 (1). pp. 85-91. ISSN 1980-5764

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Abstract

Background: Spatial orientation is emerging as an early and reliable cognitive biomarker of Alzheimer’s disease (AD) pathophysiology. However, no evidence exists as to whether spatial orientation is also affected in vascular dementia (VaD). Objective: To examine allocentric (map-based) and egocentric (viewpoint-based) spatial orientation in an early stage VaD case. Methods: A spatial test battery was administered following clinical and neuropsychological cognitive evaluation. Results: Despite the patient’s complaints, little evidence of episodic memory deficits were detected when cueing was provided to overcome executive dysfunction. Similarly, medial temporal lobe-mediated allocentric orientation was intact. By contrast, medial parietal-mediated egocentric orientation was impaired, despite normal performance on standard visuospatial tasks. Conclusion: To our knowledge, this is the first in-depth investigation of spatial orientation deficits in VaD. Isolated egocentric deficits were observed. This differs from AD orientation deficits which encompass both allocentric and egocentric orientation deficits. A combination of egocentric orientation and executive function tests could serve as a promising cognitive marker for VaD pathophysiology.

Item Type: Article
Uncontrolled Keywords: spatial orientation,egocentric,allocentric,vascular dementia,vad,executive function,neurodegeneration
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Social Sciences > School of Psychology
Faculty of Medicine and Health Sciences > School of Health Sciences
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Depositing User: Pure Connector
Date Deposited: 12 Feb 2018 10:30
Last Modified: 22 Jul 2020 01:59
URI: https://ueaeprints.uea.ac.uk/id/eprint/66264
DOI: 10.1590/1980-57642018dn12-010013

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