Improved coronary magnetic resonance angiography using gadobenate dimeglumine in pediatric congenital heart disease

Vieira, Miguel Silva, Henningsson, Markus, Dedieu, Nathalie, Vassiliou, Vassilios S. ORCID: https://orcid.org/0000-0002-4005-7752, Bell, Aaron, Mathur, Sujeev, Pushparajah, Kuberan, Figueroa, Carlos Alberto, Hussain, Tarique, Botnar, René and Greil, Gerald F (2018) Improved coronary magnetic resonance angiography using gadobenate dimeglumine in pediatric congenital heart disease. Magnetic Resonance Imaging, 49. 47–54. ISSN 0730-725X

[thumbnail of Accepted manuscript]
Preview
PDF (Accepted manuscript) - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (14MB) | Preview

Abstract

Background: CMRA in pediatrics remains challenging due to the smaller vessel size, high heart rates (HR), potential image degradation caused by limited patient cooperation and long acquisition times. High-relaxivity contrast agents have been shown to improve coronary imaging in adults, but limited data is available in children. We sought to investigate whether gadobenate dimeglumine (Gd-BOPTA) together with self-navigated inversion-prepared coronary magnetic resonance angiography (CMRA) sequence design improves coronary image quality in pediatric patients. Methods: Forty consecutive patients (mean age 6 ± 2.8 years; 73% males) were prospectively recruited for a 1.5-T MRI study under general anesthesia. Two electrocardiographic-triggered free breathing steady-state free precession (SSFP) angiography sequences (A and B) with isotropic spatial resolution (1.3 mm3) were acquired using a recently developed image-based self-navigation technique. Sequence A was acquired prior to contrast administration using T2 magnetization preparation (T2prep). Sequence B was acquired 5–8 min after a bolus of Gd-BOPTA with the T2prep replaced by an inversion recovery (IR) pulse to null the signal from the myocardium. Scan time, signal-to noise and contrast-to-noise ratios (SNR and CNR), vessel wall sharpness (VWS) and qualitative visual score for each sequence were compared. Results: Scan time was similar for both sequences (5.3 ± 1.8 vs 5.2 ± 1.5 min, p = .532) and average heart rate (78 ± 14.7 vs 78 ± 14.5 bpm, p = .443) remained constant throughout both acquisitions. Sequence B resulted in higher SNR (12.6 ± 4.4 vs 31.1 ± 7.4, p < .001) and CNR (9.0 ± 1.8 vs 13.5 ± 3.7, p < .001) and provided improved coronary visualization in all coronary territories (VWS A = 0.53 ± 0.07 vs B = 0.56 ± 0.07, p = .001; and visual scoring A = 3.8 ± 0.59 vs B = 4.1 ± 0.53, p < .001). The number of non-diagnostic coronary segments was lower for sequence B [A = 42 (13.1%) segments vs B = 33 (10.3%) segments; p = .002], and contrary to the pre-contrast sequence, never involved a proximal segment. These results were independent of the patients' age, body surface area and HR. Conclusions: The use of Gd-BOPTA with a 3D IR SSFP CMRA sequence results in improved coronary visualization in small infants and young children with high HR within a clinically acceptable scan time.

Item Type: Article
Uncontrolled Keywords: gadobenate dimeglumine,respiratory image-based navigation,coronary magnetic resonance angiography,pediatric congenital heart disease
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Pure Connector
Date Deposited: 23 Jan 2018 10:30
Last Modified: 22 Oct 2022 03:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/66033
DOI: 10.1016/j.mri.2017.12.023

Actions (login required)

View Item View Item