Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system

Wang, Guang, Liang, Jianxin, Gao, Lin-rui, Si, Zhen-peng, Zhang, Xiao-tan, Liang, Guo, Yan, Yu, Li, Ke, Cheng, Xin, Bao, Yongping, Chuai, Manli, Chen, Li-guo, Lu, Da-xiang and Yang, Xuesong (2018) Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system. Cell Death & Disease, 9. ISSN 2041-4889

[img] PDF (Accepted manuscript) - Submitted Version
Restricted to Repository staff only until 31 December 2099.

Download (576kB) | Request a copy
[img]
Preview
PDF (baicalin_administration_CDaD_2018) - Published Version
Available under License Creative Commons Attribution.

Download (3MB) | Preview

Abstract

In this study, the effects of Baicalin on the hyperglycemia-induced cardiovascular malformation during embryo development were investigated. Using early chick embryos, an optimal concentration of Baicalin (6 μM), was identified which could prevent hyperglycemia-induced cardiovascular malformation of embryos. Hyperglycemia-enhanced cell apoptosis was reduced in embryos and HUVECs in the presence of Baicalin. Hyperglycemia-induced excessive ROS production was inhibited when Baicalin was administered. Analyses of SOD, GSH-Px, MAQE and GABAA suggested Baicalin plays an antioxidant role in chick embryos possibly through suppression of outwardly rectifying Cl(-) in the high-glucose microenvironment. In addition, hyperglycemia-enhanced autophagy fell in the presence of Baicalin, through affecting the ubiquitin of p62 and accelerating autophagy flux. Both Baicalin and Vitamin C could decrease apoptosis, but CQ did not, suggesting autophagy to be a protective function on the cell survival. In mice, Baicalin reduced the elevated blood glucose level caused by streptozotocin (STZ). Taken together, these data suggest that hyperglycemia-induced embryonic cardiovascular malformation can be attenuated by Baicalin administration through suppressing the excessive production of ROS and autophagy. Baicalin could be a potential candidate drug for women suffering from gestational diabetes mellitus.

Item Type: Article
Uncontrolled Keywords: baicalin,angiogenesis,heart tube formation,apoptosis ,ros
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 18 Jan 2018 16:30
Last Modified: 02 May 2020 23:46
URI: https://ueaeprints.uea.ac.uk/id/eprint/66011
DOI: 10.1038/s41419-018-0318-2

Actions (login required)

View Item View Item