Validity and Reliability of the Frontotemporal Dementia Rating Scale (FTD-FRS) for the Progression and Staging of Dementia in Brazilian Patients

Lima-Silva, Thaís B., S. Bahia, Valéria, A. Cecchini, Mário, Cassimiro, Luciana, C. Guimarães, Henrique, B. Gambogi, Leandro, Caramelli, Paulo, Balthazar, Márcio, Damasceno, Benito, Brucki, Sônia M. D., C. de Souza, Leonardo, Nitrini, Ricardo, Mioshi, Eneida and S. Yassuda, Mônica (2018) Validity and Reliability of the Frontotemporal Dementia Rating Scale (FTD-FRS) for the Progression and Staging of Dementia in Brazilian Patients. Alzheimer Disease and Associated Disorders, 32 (3). 220–225. ISSN 0893-0341

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Abstract

Introduction: Few studies on instruments for staging frontotemporal dementia (FTD) have been conducted.  Objective: The objective of this study was to analyze the factor structure, internal consistency, reliability, and convergent validity of the Brazilian version of the Frontotemporal Dementia Rating Scale (FTD-FRS).  Methods: A total of 97 individuals aged 40 years and above with >2 years’ education took part in the study, 31 patients diagnosed with behavioral variant FTD (bvFTD), 8 patients with primary progressive aphasia, 28 with Alzheimer disease, 8 with mild cognitive impairment, and a control group of 22 healthy subjects. The FTD-FRS was completed by family members or caregivers, and Neurologists completed the 8-item Clinical Dementia Rating for Frontotemporal Lobar Degeneration (CDR-FTLD) scale (6 original domains plus Language and Behavior). The Alzheimer disease and FTD patients had equivalent disease severity level.  Results: The internal consistency of the FTD-FRS, estimated by Cronbach α, was 0.975 whereas test-retest reliability was 0.977. Scree plot and exploratory factor (Varimax rotation) analyses revealed the existence of 4 factors, with eigenvalues >1, which together explained 77.13% of the total variance with values of 1.28 to 17.52. The domains of the Brazilian version of the FTD-FRS scale correlated with the domains of the CDR-FTLD.  Conclusions: The present study is the first to document the factorial structure of the FTD-FRS and its convergent validity with the CDR-FTLD. These tools are key to determine dementia severity in FTD. The Brazilian FTD-FRS demonstrated adequate psychometric properties for use in Brazil. This instrument may contribute to disease staging in FTD and may help to document intervention-related changes.

Item Type: Article
Uncontrolled Keywords: staging,dementia progression,frontotemporal dementia,behavioral variant frontotemporal dementia,primary progressive aphasia
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Depositing User: Pure Connector
Date Deposited: 15 Jan 2018 15:33
Last Modified: 01 Aug 2020 23:42
URI: https://ueaeprints.uea.ac.uk/id/eprint/65931
DOI: 10.1097/WAD.0000000000000246

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