Pan-Domain Analysis of ZIP Zinc Transporters

Lehtovirta-Morley, Laura E., Alsarraf, Mohammed and Wilson, Duncan (2017) Pan-Domain Analysis of ZIP Zinc Transporters. International Journal of Molecular Sciences, 18 (12). ISSN 1661-6596

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Abstract

The ZIP (Zrt/Irt-like protein) family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution, or their origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, Candida albicans. Pan-domain analysis of bacterial, archaeal, fungal, and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers, (ii) a fungal-specific group of zinc importers having genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal, and eukaryotic phyla.

Item Type: Article
Uncontrolled Keywords: zip,zinc,transport,transporter,evolution,pathogenic fungi,candida albicans
Faculty \ School: Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: Pure Connector
Date Deposited: 20 Dec 2017 06:07
Last Modified: 15 Aug 2020 23:40
URI: https://ueaeprints.uea.ac.uk/id/eprint/65783
DOI: 10.3390/ijms18122631

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