Enhanced resting-state functional connectivity between core memory-task activation peaks is associated with memory impairment in MCI

Zhang, Yifei, Simon-Vermot, Lee, Araque Caballero, Miguel Á., Gesierich, Benno, Taylor, Alexander N.W., Duering, Marco, Dichgans, Martin, Ewers, Michael and , Alzheimer's Disease Neuroimaging Initiative (2016) Enhanced resting-state functional connectivity between core memory-task activation peaks is associated with memory impairment in MCI. Neurobiology of Aging, 45. pp. 43-49. ISSN 0197-4580

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Abstract

Resting-state functional connectivity (FC) is altered in Alzheimer's disease (AD) but its predictive value for episodic memory impairment is debated. Here, we aimed to assess whether resting-state FC in core brain regions activated during memory-task functional magnetic resonance imaging is altered and predictive of memory performance in AD and amnestic mild cognitive impairment (aMCI). Twenty-three elderly cognitively healthy controls (HC), 76 aMCI subjects, and 19 AD dementia patients were included. We computed resting-state FC between 18 meta-analytically determined peak coordinates of brain activation during successful memory retrieval. Higher FC between the parahippocampus, parietal cortex, and the middle frontal gyrus was observed in both AD and mild cognitive impairment compared to HC (false-discovery rate—corrected p < 0.05). The increase in FC between the parahippocampus and middle frontal gyrus was associated with reduced episodic memory in aMCI, independent of amyloid-beta positron emission tomography binding and apolipoprotein E ε4-carrier status. In conclusion, increased parahippocampal-prefrontal FC is predictive of impaired episodic memory in aMCI and may reflect a dysfunctional change within the episodic memory–related neural network.

Item Type: Article
Uncontrolled Keywords: alzheimer's disease,functional connectivity,episodic memory,mild cognitive impairment,resting-state functional mri,compensation,network
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: Pure Connector
Date Deposited: 30 Nov 2017 06:06
Last Modified: 22 Apr 2020 05:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/65634
DOI: 10.1016/j.neurobiolaging.2016.04.018

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