Tract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease

Taylor, Alexander N.W., Kambeitz-Ilankovic, Lana M., Gesierich, Benno, Simon-Vermot, Lee, Franzmeier, Nicolai, Araque Caballero, Miguel Á., Müller, Sophia, Hesheng, Liu, Ertl-Wagner, Birgit, Bürger, Katharina, Weiner, Michael W., Dichgans, Martin, Duering, Marco and Ewers, Michael and Alzheimer's Disease Neuroimaging Initiative (2017) Tract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease. Alzheimer's and Dementia, 13 (3). pp. 225-235. ISSN 1552-5260

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Introduction: White matter hyperintensities (WMHs) increase the risk of Alzheimer's disease (AD). Whether WMHs are associated with the decline of functional neural networks in AD is debated. Method: Resting-state functional magnetic resonance imaging and WMH were assessed in 78 subjects with increased amyloid levels on AV-45 positron emission tomography (PET) in different clinical stages of AD. We tested the association between WMH volume in major atlas-based fiber tract regions of interest (ROIs) and changes in functional connectivity (FC) between the tracts' projection areas within the default mode network (DMN). Results: WMH volume within the inferior fronto-occipital fasciculus (IFOF) was the highest among all tract ROIs and associated with reduced FC in IFOF-connected DMN areas, independently of global AV-45 PET. Higher AV-45 PET contributed to reduced FC in IFOF-connected, temporal, and parietal DMN areas. Conclusions: High fiber tract WMH burden is associated with reduced FC in connected areas, thus adding to the effects of amyloid pathology on neuronal network function.

Item Type: Article
Uncontrolled Keywords: alzheimer's disease,functional connectivity,fiber tract,resting-state fmri,white matter hyperintensities,vascular,amyloid-beta
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: Pure Connector
Date Deposited: 09 Nov 2017 06:07
Last Modified: 03 Nov 2022 15:44
DOI: 10.1016/j.jalz.2016.06.2358


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