The role of vitamin D in disease progression in early Parkinson’s disease

Sleeman, Isobel, Aspray, Terry, Lawson, Rachael, Coleman, Shirley, Duncan, Gordon, Khoo, Tien K., Schoenmakers, Inez, Rochester, Lynn, Burn, David and Yarnall, Alison (2017) The role of vitamin D in disease progression in early Parkinson’s disease. Journal of Parkinson's Disease, 7 (4). pp. 669-675. ISSN 1877-7171

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Abstract

Background: Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25-hydroxy vitamin D (25(OH)D) concentrations than controls. Vitamin D deficiency was associated with increased disease severity and cognitive impairment in prevalent PD patients. Objective: The aim of the study was to determine 25(OH)D in newly diagnosed PD and age-matched controls and to assess if there was an association with clinical outcomes (disease severity, cognition and falls) over the 36-month follow up period. Methods: A prospective observational study of newly diagnosed PD patients in the North East of England with age-matched controls (PD, n = 145; control, n = 94). Serum 25(OH)D was assessed at baseline and 18 months. Participants underwent clinical assessment at baseline, 18 and 36 months. One hundred and ten participants with PD also took part in a prospective falls study. Results: Mean serum 25(OH)D concentrations were lower in PD than control participants at baseline (44.1±21.7 vs. 52.2±22.1 nmol/L, p < 0.05) and 18 months (44.2±23.6 vs. 55.7±28.8 nmol/L, p < 0.05). Baseline serum 25(OH)D concentration, age, motor score and dosage of dopaminergic medication were significant predictors of variance of motor severity at 36 months ((ΔR2 = 0.039, F = 6.6, p < 0.01). Serum 25(OH)D was not associated with cognition or falls during the follow up period. Conclusions: Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls, which may have implications in terms of bone health and fracture risk. There was a small but significant association between vitamin D status at baseline and disease motor severity at 36 months.

Item Type:	Article
Uncontrolled Keywords:	balance,cognition,disease progression,fall,25-hydroxy vitamin d,parkinson’s disease,vitamin d
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Related URLs:	http://www.medra.org/servlet/aliasResolv...
Depositing User:	Pure Connector
Date Deposited:	08 Nov 2017 06:05
Last Modified:	10 Jul 2023 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/65365
DOI:	10.3233/JPD-171122

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