A systematic review of cost-ofiIllness studies of multimorbidity

Wang, Lili, Si, Lei, Cocker, Fiona, Palmer, Andrew J. and Sanderson, Kristy ORCID: https://orcid.org/0000-0002-3132-2745 (2018) A systematic review of cost-ofiIllness studies of multimorbidity. Applied Health Economics and Health Policy, 16 (1). 15–29. ISSN 1175-5652

[thumbnail of Accepted manuscript]
PDF (Accepted manuscript) - Accepted Version
Download (406kB) | Preview


Objectives: The economic burden of multimorbidity is considerable. This review analyzed the methods of cost-of-illness (COI) studies and summarized the economic outcomes of multimorbidity. Methods: A systematic review (2000–2016) was performed, which was registered with Prospero, reported according to PRISMA, and used a quality checklist adapted for COI studies. The inclusion criteria were peer-reviewed COI studies on multimorbidity, whereas the exclusion criterion was studies focusing on an index disease. Extracted data included the definition, measure, and prevalence of multimorbidity; the number of included health conditions; the age of study population; the variables used in the COI methodology; the percentage of multimorbidity vs. total costs; and the average costs per capita. Results: Among the 26 included articles, 14 defined multimorbidity as a simple count of 2 or more conditions. Methodologies used to derive the costs were markedly different. Given different healthcare systems, OOP payments of multimorbidity varied across countries. In the 17 and 12 studies with cut-offs of ≥2 and ≥3 conditions, respectively, the ratios of multimorbidity to non-multimorbidity costs ranged from 2–16 to 2–10. Among the ten studies that provided cost breakdowns, studies with and without a societal perspective attributed the largest percentage of multimorbidity costs to social care and inpatient care/medicine, respectively. Conclusion: Multimorbidity was associated with considerable economic burden. Synthesising the cost of multimorbidity was challenging due to multiple definitions of multimorbidity and heterogeneity in COI methods. Count method was most popular to define multimorbidity. There is consistent evidence that multimorbidity was associated with higher costs.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Depositing User: Pure Connector
Date Deposited: 14 Sep 2017 05:05
Last Modified: 21 Oct 2022 16:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/64861
DOI: 10.1007/s40258-017-0346-6

Actions (login required)

View Item View Item