Diet, the intestinal microbiota, and immune health in aging

Clements, Sarah J. and R. Carding, Simon (2018) Diet, the intestinal microbiota, and immune health in aging. Critical Reviews in Food Science and Nutrition, 58 (4). pp. 651-661. ISSN 1040-8398

[thumbnail of Published manuscript]
PDF (Published manuscript) - Published Version
Available under License Creative Commons Attribution.

Download (883kB) | Preview


Many countries are facing aging populations, with those over 65 years of age likely to represent the largest population over the next 10–20 years. Living longer often comes with poor health and, in particular, a decline in the immune function characterized by poor vaccine responses and increased risk of infection and certain cancers. Aging and diet represent major intrinsic and extrinsic factors that influence the makeup and activity of resident intestinal microbes, the microbiota, the efficient functioning of which is essential for sustaining overall health and the effectiveness of the immune system. The provision of elderly specific dietary recommendations appears to be lacking but is necessary since this population has an altered microbiota and immune response and may not respond in the same way as their healthy and younger counterparts. We have reviewed the evidence supporting the role of diet and, in particular, dietary carbohydrate, protein, and fat in influencing the microbiota and its generation of key metabolites that influence the efficient functioning of immune cells during aging, and how dietary intervention might be of benefit in improving the intestinal health and immune status in the elderly.

Item Type: Article
Uncontrolled Keywords: elderly,immunosenescence,short chain fatty acids,microbiota,fiber,protein,fat,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Related URLs:
Depositing User: Pure Connector
Date Deposited: 05 Aug 2017 05:06
Last Modified: 22 Oct 2022 02:58
DOI: 10.1080/10408398.2016.1211086


Downloads per month over past year

Actions (login required)

View Item View Item