Modulation of proprioceptive feedback during functional electrical stimulation:an fMRI study

Christensen, Mark Schram and Grey, Michael James ORCID: (2013) Modulation of proprioceptive feedback during functional electrical stimulation:an fMRI study. European Journal of Neuroscience, 37 (11). pp. 1766-1778. ISSN 0953-816X

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Functional electrical stimulation (FES) is sometimes used as a therapeutic modality in motor rehabilitation to augment voluntary motor drive to effect movement that would otherwise not be possible through voluntary activation alone. Effective motor rehabilitation should require that the central nervous system integrate efferent commands and appropriate afferent information to update the internal models of acquired skills. Here, we investigate whether FES-evoked (FES-ev) and FES-assisted (FES-as) movement are associated with the normal integration of motor commands and sensory feedback in a group of healthy participants during functional magnetic resonance imaging (fMRI). Sensory feedback was removed with a peripheral ischaemic nerve block while the participants performed voluntary (VOL), FES-ev or FES-as movement during fMRI. Before the peripheral nerve block, secondary somatosensory area (S2) activation was greater for the FES-ev and FES-as conditions than for the VOL condition. During the ischaemic nerve block, S2 activation was reduced for the FES-ev condition but not for FES-as and VOL conditions. The nerve block also reduced activation during FES in the primary somatosensory cortex and other motor areas including primary motor cortex, dorsal premotor cortex and supplementary motor area. In contrast, superior parietal lobule (area 7A) and precuneus activation was reduced as a consequence of the ischaemic nerve block in the VOL condition. These data suggest FES-related S2 activation is mainly a sensory phenomenon and does not reflect integration of sensory signals with motor commands.

Item Type: Article
Additional Information: © 2013 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
Uncontrolled Keywords: functional magnetic resonance imaging,motor control,motor system,sensorimotor integration,somatosensory system
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Rehabilitation
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Depositing User: Pure Connector
Date Deposited: 27 Jun 2017 05:06
Last Modified: 12 May 2023 04:30
DOI: 10.1111/ejn.12178

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