Overview of systematic reviews of therapeutic ranges: methodologies and recommendations for practice

Cooney, Lewis, Loke, Yoon K., Golder, Su, Kirkham, Jamie, Jorgensen, Andrea, Sinha, Ian and Hawcutt, Daniel (2017) Overview of systematic reviews of therapeutic ranges: methodologies and recommendations for practice. BMC Medical Research Methodology, 17. ISSN 1471-2288

[thumbnail of Published manuscript]
PDF (Published manuscript) - Published Version
Available under License Creative Commons Attribution.

Download (573kB) | Preview


Background: Many medicines are dosed to achieve a particular therapeutic range, and monitored using therapeutic drug monitoring (TDM). The evidence base for a therapeutic range can be evaluated using systematic reviews, to ensure it continues to reflect current indications, doses, routes and formulations, as well as updated adverse effect data. There is no consensus on the optimal methodology for systematic reviews of therapeutic ranges. Methods: An overview of systematic reviews of therapeutic ranges was undertaken. The following databases were used: Cochrane Database of Systematic Reviews (CDSR), Database of Abstracts and Reviews of Effects (DARE) and MEDLINE. The published methodologies used when systematically reviewing the therapeutic range of a drug were analyzed. Step by step recommendations to optimize such systematic reviews are proposed. Results: Ten systematic reviews that investigated the correlation between serum concentrations and clinical outcomes encompassing a variety of medicines and indications were assessed. There were significant variations in the methodologies used (including the search terms used, data extraction methods, assessment of bias, and statistical analyses undertaken). Therapeutic ranges should be population and indication specific and based on clinically relevant outcomes. Recommendations for future systematic reviews based on these findings have been developed. Conclusion: Evidence based therapeutic ranges have the potential to improve TDM practice. Current systematic reviews investigating therapeutic ranges have highly variable methodologies and there is no consensus of best practice when undertaking systematic reviews in this field. These recommendations meet a need not addressed by standard protocols.

Item Type: Article
Uncontrolled Keywords: systematic review methodology,therapeutic range,systematic review
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Pure Connector
Date Deposited: 24 Jun 2017 05:06
Last Modified: 20 Apr 2023 00:29
URI: https://ueaeprints.uea.ac.uk/id/eprint/63833
DOI: 10.1186/s12874-017-0363-z

Actions (login required)

View Item View Item