The Role of Endothelial αvβ3 Integrin in Metastasis

Chenoweth, Hannah (2016) The Role of Endothelial αvβ3 Integrin in Metastasis. Masters thesis, University of East Anglia.

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Abstract

The integrin αvβ3 is part of a family of membrane proteins with bi-directional signalling and activity. In this way αvβ3 plays an extensive and complex role in cancer biology. This study builds on results that show that knocking out αvβ3 in endothelial cells reduces cancer metastasis suggesting that endothelial αvβ3 plays a pro-metastatic role. In particular, there has been a focus on the pre-metastatic niche, a pro-metastatic environment set up by the primary tumour before metastatic growth. In this vein, changes to pre-metastatic environments have been studied via immune cell and cytokine profiling. To do this FACS and quantitative analysis of immunohistochemistry has been performed. While this study does not bring about a conclusive explanation of the pro-metastatic role of endothelial αvβ3, it opens up other areas of research. These include identifying changes in specific myeloid populations such as polarised neutrophils and identifying differences in the endothelial layer at metastatic sites.

Item Type: Thesis (Masters)
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: Katie Miller
Date Deposited: 16 Jun 2017 15:10
Last Modified: 16 Jun 2017 15:10
URI: https://ueaeprints.uea.ac.uk/id/eprint/63756
DOI:

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