Studies towards a total synthesis of tagetitoxin

Mahoney, Brian (2017) Studies towards a total synthesis of tagetitoxin. Doctoral thesis, University of East Anglia.

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Abstract

Tagetitoxin was first isolated over thirty five years ago and a total synthesis has not been
achieved to date. A vast amount of research has been carried out on the biological activity of
tagetitoxin with hundreds of literature reports. However, very few papers have been published
regarding the synthesis and within this thesis we will explore a number of synthetic pathways
some towards tagetitoxin.
The first chapter reviews previous developments regarding the total synthesis of tagetitoxin. It
also covers the discovery and biological work that has being carried out in identifying the
structure and the biological activity of tagetitoxin.
The second part reports my studies towards a total synthesis of tagetitoxin. It details all the
routes explored showing the key intermediates and novel compounds we obtained.
The third and final part contains the experimental data for all compounds discussed in part two
of this thesis.

Item Type: Thesis (Doctoral)
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Katie Miller
Date Deposited: 16 Jun 2017 15:00
Last Modified: 16 Jun 2017 15:00
URI: https://ueaeprints.uea.ac.uk/id/eprint/63755
DOI:

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