Signaling Events during Swelling and Regulatory Volume Decrease

Pasantes-Morales, Herminia, Cardin, Velia and Tuz, Karina (2000) Signaling Events during Swelling and Regulatory Volume Decrease. Neurochemical Research, 25 (9). pp. 1301-1314. ISSN 0364-3190

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Abstract

Brain cell swelling compromises neuronal function and survival by the risk of generation of ischemia episodes as compression of small vessels occurs due to the limits to expansion imposed by the rigid skull. External osmolarity reductions or intracellular accumulation of osmotically active solutes result in cell swelling which can be counteracted by extrusion of osmolytes through specific efflux pathways. Characterization of these pathways has received considerable attention, and there is now interest in the understanding of the intracellular signaling events involved in their activation and regulation. Calcium and calmodulin, phosphoinositides and cAMP may act as second messengers, carrying the information about a cell volume change into signaling enzymes. Small GTPases, protein tyrosine kinases and phospholipases, also appear to be part of the signaling cascades ultimately modulating the osmolyte efflux pathways. This review focus on i) the influence of hyposmotic and isosmotic swelling on these signaling events and molecules and ii) the effects of manipulating their function on the osmolyte fluxes, particularly K+, CI− and amino acids, and on the consequent efficiency of cell volume adjustment.

Item Type: Article
Faculty \ School: Faculty of Social Sciences > School of Psychology
Related URLs:
Depositing User: Pure Connector
Date Deposited: 06 Apr 2017 07:00
Last Modified: 22 Apr 2020 03:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/63183
DOI: 10.1023/A:1007652330703

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