A meta-analysis of stroke risk following herpes zoster infection

Marra, Fawziah, Ruckenstein, Jeremy and Richardson, Kathryn ORCID: https://orcid.org/0000-0002-0741-8413 (2017) A meta-analysis of stroke risk following herpes zoster infection. BMC Infectious Diseases, 17. ISSN 1471-2334

[thumbnail of Published manuscript]
PDF (Published manuscript) - Published Version
Available under License Creative Commons Attribution.

Download (711kB) | Preview


Background: The incidence of herpes zoster (HZ) is increasing and poses a significant health concern to aging populations. Several studies suggest an increased risk of stroke following zoster infection, but the results are conflicting. We conducted a systematic review and meta-analysis to determine if stroke risk is increased following HZ infection. Methods: A search of MEDLINE, EMBASE, Google scholar, Web of Science, CAB Direct, Cumulative Index to Nursing and Allied Health Literature, and Evidence Based Medicine Reviews was conducted for observational studies of adults with HZ infection that examined stroke and TIA risk from January 1, 1966 to May 31, 2016. Adjusted relative risks reported for similar follow-up durations were pooled across studies separately using random-effects inverse variance models. Results: Data were pooled from nine studies. Relative risk for stroke after zoster was 1.78 (95% CI 1.70–1.88) for the first month following herpes zoster, dropping progressively to 1.43 (95% CI 1.38–1.47) after 3 months, to 1.20 (95% CI 1.14–1.26) after 1 year. We found that stroke risk increases by a larger margin during the first month after a herpes zoster ophthalmicus episode: relative risk 2.05 (95% CI 1.82–2.31). The risk remains elevated one year after the acute episode. Conclusions: Herpes zoster is an established risk factor for increasing the risk of stroke, especially shortly after infection. Vaccination should be encouraged in patients at high risk of cardiovascular disease.

Item Type: Article
Uncontrolled Keywords: herpes zoster,meta-analysis,stroke,transient ischemic attacks,tia,aging,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Health Promotion
Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Related URLs:
Depositing User: Pure Connector
Date Deposited: 28 Mar 2017 00:41
Last Modified: 19 Apr 2023 20:33
URI: https://ueaeprints.uea.ac.uk/id/eprint/63093
DOI: 10.1186/s12879-017-2278-z


Downloads per month over past year

Actions (login required)

View Item View Item